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117-08-8 - Tetrachlorophthalic anhydride, 98% - A17404 - Alfa Aesar

A17404 Tetrachlorophthalic anhydride, 98%

CAS Number
117-08-8
Synonyms

Size Price ($) Quantity Availability
500g 36.05
2500g 112.50
10000g 432.60
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Tetrachlorophthalic anhydride, 98%

MDL
MFCD00005920
EINECS
204-171-4

Chemical Properties

Formula
C8Cl4O3
Formula Weight
285.90
Melting point
254-258°
Boiling Point
349-354°
Flash Point
362°(683°F)
Sensitivity
Moisture Sensitive
Solubility
Hydrolyzes slowly in water.

Applications

Protection of amines as their tetrachlorophthalimide derivatives, by reaction with the anhydride in the presence of triethylamine, has been found to be useful in oligosaccharide chemistry. The group is stable to a wide range of reagents but can be selectively cleaved with ethylenediamine at lower temperatures than for the parent phthalimide derivatives; in particular, carboxylic esters are not cleaved under these conditions.

Notes

Hygroscopic. Store away from oxidizing agents, acids.

Literature References

Wilfred Howe, A.F.O.M., M.R.C.G.P.; Katherine M. Venables, M.Sc., M.R.C.P.; Michael D. Topping, Ph.D.; Michael B. Dally, M.R.A.C.P.; Rosemarie Hawkins, S.R.N.; J.Stephen Law, M.D.; Anthony J.Newman Taylor, M.Sc., M.R.C.P. Tetrachlorophthalic anhydride asthma: evidence for specific IgE antibody Journal of Allergy and Clinical Immunology. 1983, 71 (1), 5-11.

Gary M. Liss, MD, MS, FRCPC.; David Bernstein, MD.; Leon Genesove, MD, FRCPC.; Jaan O. Roos, MD, FRCPC.; Janet Lim, MD. Assessment of risk factors for IgE-mediated sensitization to tetrachlorophthalic anhydride. Journal of Allergy and Clinical Immunology. 1993, 92 ( 237-247),.

Protection of amines as their tetrachlorophthalimide derivatives, by reaction with the anhydride in the presence of triethylamine, has been found to be useful in oligosaccharide chemistry. The group is stable to a wide range of reagents but can be selectively cleaved with ethylenediamine at lower temperatures than for the parent phthalimide derivatives; in particular, carboxylic esters are not cleaved under these conditions: J. Am. Chem. Soc., 117, 3302 (1995); J. Org. Chem., 61, 432 (1996).

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H317-H318-H400-H410

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Causes serious eye damage. Very toxic to aquatic life. Very toxic to aquatic life with long lasting effects.

Precautionary Statements: P285-P261-P273-P280-P305+P351+P338-P310-P342+P311-P363-P304+P341-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
211560
Hazard Class
9
Packing Group
III
Harmonized Tariff Code
2917.39
TSCA
Yes
RTECS
TI3450000

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