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3376-24-7 - N-tert-Butyl-alpha-phenylnitrone, 98% - PBN - alpha-Phenyl-N-tert-butylnitrone - A17442 - Alfa Aesar

A17442 N-tert-Butyl-alpha-phenylnitrone, 98%

CAS Number
3376-24-7
Synonyms
PBN
alpha-Phenyl-N-tert-butylnitrone

Size Price ($) Quantity Availability
1g 50.40
5g 202.00
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N-tert-Butyl-alpha-phenylnitrone, 98%

MDL
MFCD00008799
EINECS
222-168-6

Chemical Properties

Formula
C11H15NO
Formula Weight
177.25
Melting point
71-75°
Solubility
Soluble in DMSO (10 mg/ml), chloroform (50 mg/ml), and water (20 mg/ml).

Applications

N-tert-Butyl-a-phenylnitrone is a commonly-used free radical trap. It contains radical scavenging activity and an ability to inhibit Cox-2 (cyclooxygenase-2). N-tert-Butyl-a-phenylnitrone is an antioxidant that has been shown to act as a protective agent in several experimental models of neurodegenerative disorders. N-tert-Butyl-a-phenylnitrone inhibits lipid peroxidation in rat liver microsomes. It also prevents the induction of inducible nitric oxide synthase (iNOS) by reactive oxygen species.

Notes

Store in a cool place. Reactive with oxidizing agents.

Literature References

Edward G. Janzen.; C. Anderson Evans. Rate constants for the addition of phenyl radicals to N-(tert-butyl)-.alpha.-phenylnitrone (spin trapping) and benzene (phenylation) as studied by electron spin resonance. J. Am. Chem. Soc. 1975, 97 (1), 205-206.

Xianghui Cao.; John W. Phillis. α-Phenyl-tert-butyl-nitrone reduces cortical infarct and edema in rats subjected to focal ischemia. Brain Research. 1994, 644 (2), 267-272.

For examples of 1,3-dipolar cycloaddition reactions, see N,ɑ-Diphenyl­ nitrone, L00185.

Other References

Merck
14,7056
Beilstein
2044028
Harmonized Tariff Code
2929.90
TSCA
Yes

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