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4083-64-1 - p-Toluenesulfonyl isocyanate, 95% - Tosyl isocyanate - A17492 - Alfa Aesar

A17492 p-Toluenesulfonyl isocyanate, 95%

CAS Number
4083-64-1
Synonyms
Tosyl isocyanate

Size Price ($) Quantity Availability
25g 15.80
100g 28.90
500g 93.40
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p-Toluenesulfonyl isocyanate, 95%

MDL
MFCD00002030
EINECS
223-810-8

Chemical Properties

Formula
C8H7NO3S
Formula Weight
197.21
Melting point
Boiling Point
144°/10mm
Flash Point
145°(293°F)
Density
1.295
Refractive Index
1.5350
Sensitivity
Moisture Sensitive
Solubility
Reacts with water.

Applications

It is a reagent used to prepare acetylated syn-1,2-diols,oxazolidin-2-ones, 2,3-diamino acids, and N-tosylcarbonamides. -Toluenesulfonyl isocyanate has been used as derivatization reagent in determination of 3-α-hydroxy tibolone in human plasma by LC-MS/MS. It is also employed in the derivatization reagent in simultaneous quantitative analysis of diethylene glycol and propylene glycol in pharmaceutical products by HPLC and as reagent in the preparation of acetylated syn-1,2-diols, oxazolidin-2-ones, 2,3-diamino acids and N-tosylcarbonamides.

Notes

Keep away from alcohols, strong bases, amines, strong oxidizing agents.

Literature References

C. King. Some Reactions of p-Toluenesulfonyl Isocyanate. J. Org. Chem. 1960, 25 (3),352-356.

Priscilla B. Bell.; Andrew. Wojcicki. Kinetic study of cycloaddition reactions of transition metal-propargyl and -.eta.1-allyl complexes with p-toluenesulfonyl isocyanate. Inorg. Chem. 1981, 20 (5),1585-1592.

Highly reactive isocyanate. For a brief feature on uses of the reagent in synthesis, see: Synlett, 2644 (2004).

GHS Hazard and Precautionary Statements

Hazard Statements: H334-H315-H319-H335

May cause allergy or asthma symptoms or breathing difficulties if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P285-P261-P280-P305+P351+P338-P304+P340-P342+P311-P362-P312-P405-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
391287
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2930.90
TSCA
Yes
RTECS
DB9032000

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