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A17492 p-Toluenesulfonyl isocyanate, 95%

CAS Number
4083-64-1
Synonyms
Tosyl isocyanate

Stock No. Size Price ($) Quantity Availability
A17492-14 25g 16.40
A17492-22 100g 30.40
A17492-36 500g 98.20
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p-Toluenesulfonyl isocyanate, 95%

MDL
MFCD00002030
EINECS
223-810-8

Chemical Properties

Formula
C8H7NO3S
Formula Weight
197.21
Melting point
Boiling Point
144°/10mm
Flash Point
145°(293°F)
Density
1.295
Refractive Index
1.5350
Storage & Sensitivity
Moisture Sensitive. Ambient temperatures.
Solubility
Reacts with water.

Applications

It is a reagent used to prepare acetylated syn-1,2-diols,oxazolidin-2-ones, 2,3-diamino acids, and N-tosylcarbonamides. -Toluenesulfonyl isocyanate has been used as derivatization reagent in determination of 3-α-hydroxy tibolone in human plasma by LC-MS/MS. It is also employed in the derivatization reagent in simultaneous quantitative analysis of diethylene glycol and propylene glycol in pharmaceutical products by HPLC and as reagent in the preparation of acetylated syn-1,2-diols, oxazolidin-2-ones, 2,3-diamino acids and N-tosylcarbonamides.

Notes

Keep away from alcohols, strong bases, amines, strong oxidizing agents.

Literature References

C. King. Some Reactions of p-Toluenesulfonyl Isocyanate. J. Org. Chem. 1960, 25 (3),352-356.

Priscilla B. Bell.; Andrew. Wojcicki. Kinetic study of cycloaddition reactions of transition metal-propargyl and -.eta.1-allyl complexes with p-toluenesulfonyl isocyanate. Inorg. Chem. 1981, 20 (5),1585-1592.

Highly reactive isocyanate. For a brief feature on uses of the reagent in synthesis, see: Synlett, 2644 (2004).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H334-H335-H336

Causes skin irritation. Causes serious eye irritation. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause respiratory irritation. May cause drowsiness or dizziness.

Precautionary Statements: P261-P264b-P271-P280-P285-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P331-P332+P313-P337+P313-P342+P311-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. In case of inadequate ventilation wear respiratory protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. Do NOT induce vomiting. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
391287
Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2930.90
TSCA
Yes
RTECS
DB9032000

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