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A17630 Benzyl bromoacetate, 97%

CAS Number
5437-45-6
Synonyms
Bromoacetic acid benzyl ester

Stock No. Size Price ($) Quantity Availability
A17630-18 50g 28.30
A17630-30 250g 97.10
A17630-0B 1000g 291.00
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Benzyl bromoacetate, 97%

MDL
MFCD00000190
EINECS
226-611-4

Chemical Properties

Formula
C6H5CH2CO2CH2Br
Formula Weight
229.08
Boiling Point
157-159°/10mm
Flash Point
>110°(230°F)
Density
1.460
Refractive Index
1.5440
Storage & Sensitivity
Ambient temperatures.
Solubility
Not miscible or difficult to mix in water.

Applications

It is employed in biological research purpose. Benzyl bromoacetate was used in the alkylation of (-)-2,3-O-isopropylidene-D-threitol that afforded lipopeptide, 2-[(4R,5R)-5-({[(9H-fluoren-9-yl)methoxy]carbonylaminomethyl}-2,2-dimethyl-1,3-dioxolan-4-yl)methoxy]acetic acid.

Notes

Store away from oxidizing agents and strong bases. Keep the container tightly closed in a cool, dry place. Store under 20?C Freezer, Under Inert Atmosphere.

Literature References

Herrin TR.; Fairgrieve JS.; Bower RR.; Shipkowitz NL. Synthesis and anti-herpes simplex activity of analogues of phosphonoacetic acid.J Med Chem.1977,20(5), 660-663.

Feagin TA.; Shah N.; Heemstra JM. Micellar. Convenient and scalable synthesis of fmoc-protected Peptide nucleic Acid backbone.J Nucleic Acids.2012,2012.

Toru Masaka.; Takuya Matsuda.; Yingpeng Li.; Yuki Koide.; Akira Takami.; Kenji Yano.; Ryosuke Imai.; Risa Ichihara.; Nobuhiro Yagi.; Hideharu Suzuki.; Hidemasa Hikawa.; Katsuhide Terada.; Yuusaku Yokoyama. Synthesis of VIP-lipopeptide using a new linker to modify liposomes: towards the development of a drug delivery system for active targeting.Chem Pharm Bull (Tokyo).2013,61(11), 1184-7.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
973658
Harmonized Tariff Code
2915.90
TSCA
No
RTECS
AF5957215

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