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832-53-1 - 2,3,4,5,6-Pentafluorobenzenesulfonyl chloride, 98+% - A17676 - Alfa Aesar

A17676 2,3,4,5,6-Pentafluorobenzenesulfonyl chloride, 98+%

CAS Number
832-53-1
Synonyms

Size Price ($) Quantity Availability
1g 18.54
5g 60.15
25g 186.40
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2,3,4,5,6-Pentafluorobenzenesulfonyl chloride, 98+%

MDL
MFCD00007427
EINECS
212-620-0

Chemical Properties

Formula
C6ClF5O2S
Formula Weight
266.57
Boiling Point
210-211°
Flash Point
90°(194°F)
Density
1.796
Refractive Index
1.4790
Sensitivity
Moisture Sensitive
Solubility
Soluble in water (reacts slowly).

Applications

Pentafluorobenzenesulfonyl chloride is used as derivatizing reagent for simultaneous determination of fluoxetine and p-trifluoromethylphenol, an O-dealkylated metabolite of fluoxetine in human liver microsomes. It is also used for electrophore labeling of small tyrosyl peptides for their analysis by gas chromatography with electron-capture detection. It is also employed as derivatizing reagent for amphetamine in determination of amphetamine in human plasma samples using gas chromatography with electron-capture detection.

Notes

Moisture Sensitive. Store away from oxidizing agents, active metals and bases, water/moisture. Keep the container tightly closed in a cool, dry place. Store under inert gas.

Literature References

Zhao-Qian Liu.; Zhi-Rong Tan.; Dan Wang.; Song-Lin Huang.; Lian-Sheng Wang.; Hong-Hao Zhou. Simultaneous determination of fluoxetine and its metabolite p-trifluoromethylphenol in human liver microsomes using a gas chromatographic-electron-capture detection procedure.J Chromatogr B Analyt Technol Biomed Life Sci.2002,769(2), 305-311.

A Sentissi.; M Joppich.; K O'Connell.; A Nazareth.; R W Giese. Pentafluorobenzenesulfonyl chloride: a new electrophoric derivatizing reagent with application to tyrosyl peptide determination by gas chromatography with electron capture detection.Anal Chem.1984,56(13), 2512-2517.

S J Asghar.; G B Baker.; G A Rauw.; P H Silverstone. A rapid method of determining amphetamine in plasma samples using pentafluorobenzenesulfonyl chloride and electron-capture gas chromatography.J Pharmacol Toxicol Methods.2001,46(2), 111-115.

GHS Hazard and Precautionary Statements

Hazard Statements: H314-H318-H227

Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Precautionary Statements: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2142325
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2904.90
TSCA
No

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