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Cyclopentanecarbonitrile is used as a substrate and reagent to investigate the specific activity of nitrile and amide hydrolyzing enzymes isolated from candida guilliermondii cells. It is also used to prepare cyclopentanecarboxamide by using tetrabutylammonium hydrogen sulfate as a catalyst in the presence of reagents such as aqueous hydrogen peroxide and sodium hydroxide.
Yang, X.; Nath, D.; Fleming, F. F. Chemoselective Alkylations with N- and C-Metalated Nitriles. Org. Lett. 2015, 17 (19), 4906-4909.
Schranck, J.; Burhardt, M.; Bornschein, C.; Neumann, H.; Skrydstrup, T.; Beller, M. Palladium-Catalyzed Carbonylative alpha-Arylation to beta-Ketonitriles. Chem. Eur. J. 2014, 20 (31), 9534-9538.
Hazard Statements: H226-H302-H312-H331-H315-H319-H335
Flammable liquid and vapour. Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.