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In combination with Paraformaldehyde, A11313, ketones undergo direct ɑ-methylenation in high yield: Tetrahedron Lett., 2111 (1978). The reaction proceeds via the Mannich intermediate. For an example (1-tetralone to its 2-methylene derivative), see: Org. Synth. Coll., 7, 332 (1990)./n
Hazard Statements: H302-H312-H332-H373
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P280h-P304+P340-P301+P312a-P321-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/clothing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell. Specific treatment (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.