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A17810 2-Bromo-5-(trifluoromethyl)aniline, 97%

CAS Number
454-79-5
Synonyms
3-Amino-4-bromobenzotrifluoride

Stock No. Size Price ($) Quantity Availability
A17810-03 1g 21.40
A17810-06 5g 70.50
A17810-14 25g 288.00
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2-Bromo-5-(trifluoromethyl)aniline, 97%

MDL
MFCD00007637
EINECS
207-227-6

Chemical Properties

Formula
C7H5BrF3N
Formula Weight
240.03
Boiling Point
81-82°/5mm
Flash Point
>110°(230°F)
Density
1.675
Refractive Index
1.5220
Storage & Sensitivity
Ambient temperatures.
Solubility
Not miscible or difficult to mix in water.

Applications

2-Bromo-5-(trifluoromethyl)aniline is used in the synthesis and biochemical evaluation of series of inhibitors of hepatitis C virus (HCV) NS3 protease.

Notes

Store away from oxidizing agents. Keep the container tightly closed in a cool, dry and well ventilated place.

Literature References

Robert Rönn.; Anna Lampa.; Shane D. Peterson.; Thomas Gossas.; Eva Åkerblom.; U. Helena Danielson.; Anders Karlén.; Anja Sandström. Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1moiety.Bioorg Med Chem.,2008,16(6), 2955-2967.

Tomoki Takeuchi.; Shinya Oishi.; Toshiaki Watanabe.; Hiroaki Ohno.; Jun-ichi Sawada.; Kenji Matsuno.; Akira Asai.; Naoya Asada.; Kazuo Kitaura.; and Nobutaka Fujii. Structure-Activity Relationships of Carboline and Carbazole Derivatives as a Novel Class of ATP-Competitive Kinesin Spindle Protein Inhibitors.J. Med. Chem.,2011,54(13), 4839-4846.

GHS Hazard and Precautionary Statements

Hazard Statements: H314

Causes severe skin burns and eye damage.

Precautionary Statements: P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2094535
Hazard Class
8
Packing Group
II
Harmonized Tariff Code
2921.43
TSCA
No

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