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78-09-1 - Tetraethyl orthocarbonate, 98+% - Tetraethoxymethane - A17835 - Alfa Aesar

A17835 Tetraethyl orthocarbonate, 98+%

CAS Number
78-09-1
Synonyms
Tetraethoxymethane

Size Price ($) Quantity Availability
5g 32.68
25g 133.20
100g 391.20
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Tetraethyl orthocarbonate, 98+%

MDL
MFCD00009221
EINECS
201-082-2

Chemical Properties

Formula
C9H20O4
Formula Weight
192.26
Boiling Point
158-161°
Flash Point
52°(125°F)
Density
0.917
Refractive Index
1.3930
Sensitivity
Moisture Sensitive
Solubility
Insoluble in water. Contact with water releases a flammable alcohol. Soluble in chloroform and methanol.

Applications

Tetraethyl Orthocarbonate is used in the synthesis of chemokine receptor-5 inhibitors against HIV-1, benzobisoxazoles and in the preparation of organic semiconductors. It is also employed in the synthesis of 2,7-dimethylene-1,4,6,9-tetraoxaspiro[4,4]nonane and in the synthesis of cross linked poly(orthocarbonate)s used as organic solvent absorbent.

Notes

Moisture Sensitive. Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Keep away from ignition sources. Store under inert atmosphere and refrigerated.

Literature References

Tagoshi H and Endo T. Radical polymerization of unsaturated spiroorthocarbonate.J. Polym. Sci. A.,1989,27(4), 1415-1418.

Sonmez HB, et al. Use of crosslinked poly (orthosilicate) s as organic solvent absorbent.Polymer Prepr.;2008,49(846).

Wieslaw M. Kazmierski.; Don L. Anderson.; Christopher Aquino.; Brian A. Chauder.; Maosheng Duan.; Robert Ferris.; Terrence Kenakin.; Cecilia S. Koble.; Dan G. Lang.; Maggie S Mcintyre.; Jennifer Peckham.; Christian Watson.; Pat Wheelan.; Andrew Spaltenstein.; Mary B. Wire.; Angilique Svolto.; and Michael Youngman. Novel 4,4-Disubstituted Piperidine-Based C-C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile.J. Med. Chem.,2011,54(11), 3756-3767.

Used to protect the 2,3-diol system of nucleosides: J. Chem. Soc., Chem. Commun., 552 (1969).

For a review of the chemistry of orthocarbonates, see: Synthesis, 73 (1977).

GHS Hazard and Precautionary Statements

Hazard Statements: H226

Flammable liquid and vapour.

Precautionary Statements: P210-P280-P240-P241-P233-P242-P243-P303+P361+P353-P403+P235-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Wear protective gloves/protective clothing/eye protection/face protection. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Keep container tightly closed. Use only non-sparking tools. Take precautionary measures against static discharge. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store in a well-ventilated place. Keep cool. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
1747401
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2920.90
TSCA
No

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