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Glutaraldehyde is used for cross-linking proteins and polyhydroxy materials. Also used as a fixative for tissues and as an amine-reactive homobifunctional crosslinker. It is also used in coupling reaction of biotin hydrazides to nucleic acids which is useful for conjugating fluorescent hydrazides and hydroxylamines to DNA and for stabilization ofproteins on agarose beads,activation of polystyrene and glass, for immobilization of antibodies and antigens.
For use in the Robinson synthesis of pseudopelletierine, see Acetone-1,3-dicarboxylic acid, A13742.
Reaction with (R)-(-)-2-Phenylglycinol, A19030, gives an intermediate for asymmetric synthesis of alkaloids: Org. Synth. Coll., 9, 176 (1998).
Cho, K. L.; Hill, A. J.; Caruso, F.; Kentish, S. E. Chlorine Resistant Glutaraldehyde Crosslinked Polyelectrolyte Multilayer Membranes for Desalination. Adv. Mater. 2015, 27 (17), 2791-2796.
Vikram, A.; Bomberger, J. M.; Bibby, K. J. Efflux as a Glutaraldehyde Resistance Mechanism in Pseudomonas fluorescens and Pseudomonas aeruginosa Biofilms. Antimicrob. Agents Chemother. 2015, 59 (6), 3433-3440.
Hazard Statements: H302-H331-H314-H318-H334-H317
Harmful if swallowed. Toxic if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.
Precautionary Statements: P260u-P284-P303+P361+P353-P305+P351+P338-P405-P501a
Wear respiratory protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.