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Used for preparation of anhydrous Li salts of carboxylic acids prior to reaction with organothium reagents (most often methyl or phenyl) as a useful route to ketones. Also used in the preparation of LiCN by reaction with acetone cyanohydrins. It is also applied as a desiccating and condensing agent and a shielding material in nuclear energy production. It is used in the manufacture of catalysts for polyolefin plastics; in fuels for aircraft, missiles. It is used in metallurgy, as degasifier, deoxidizer, desulfurizer; as grain refiner in non-ferrous metals. Employed as a chemical intermediate for butyllithium polymerization catalyst; in alloys with aluminum or magnesium for aerospace uses.
Takeshi Ohkuma.; Shohei Hashiguchi.; Ryoji Noyori. A practical method for activation of commercial lithium hydride: reductive silylation of carbonyl compounds with lithium hydride and chlorotrimethylsilane.J. Org. Chem.,1994,59(1), 217-221.
F.E. Pretzel.; G.N. Rupert.; C.L. Mader.; E.K. Storms.; G.V. Gritton.; C.C. Rushing. Properties of lithium hydride I. Single crystals.J. Phys. Chem. Solids.,1960,16(1-2), 10-20.
Used for preparation of anhydrous Li salts of carboxylic acids prior to reaction with organothium reagents (most often methyl or phenyl) as a useful route to ketones. For a comprehensive review of this method, see: Org. React., 18, 1 (1970). For an example (cyclohexyl methyl ketone), see: Org. Synth. Coll., 5, 775 (1973).
For preparation of LiCN by reaction with acetone cyanohydrin, see: Org. Synth. Coll., 7, 517 (1990).
A procedure for activation involves treatment with TMS chloride and a catalytic amount of Zn or a Zn salt. This reagent will reduce a ketone to the TMS ether of the alcohol: J. Org. Chem., 59, 217 (1994).
Hazard Statements: H261-H314
In contact with water releases flammable gas. Causes severe skin burns and eye damage.
Precautionary Statements: P223-P231+P232-P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P335+P334-P363-P370+P378q-P501c
Keep away from any possible contact with water, because of violent reaction and possible flash fire. Handle under inert gas. Protect from moisture. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician. Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant