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4-Phenoxybenzoic acid can block DNA binding of the human papillomarvirus (HPV) E2 protein. It is employed as an intermediate of Sitafloxacin, which is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer.
Mikaela Nichkova.; Dosi Dosev.; Shirley J Gee.; Bruce D Hammock.; Ian M Kennedy. Microarray immunoassay for phenoxybenzoic acid using polymer encapsulated Eu:Gd2O3 nanoparticles as fluorescent labels.Anal Chem.,2005,77(21), 6864-6873.
Hajduk PJ.; Dinges J.; Miknis GF.; Merlock M.; Middleton T.; Kempf DJ.; Egan DA.; Walter KA.; Robins TS.; Shuker SB.; Holzman TF.; Fesik SW. NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.J Med Chem.,1997,40(20), 3144-50.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.