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A17998 4-Phenoxybenzoic acid, 99%

CAS Number
2215-77-2
Synonyms
4-Carboxydiphenyl ether

Stock No. Size Price ($) Quantity Availability
A17998-06 5g 32.90
A17998-14 25g 102.00
A17998-22 100g 332.00
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4-Phenoxybenzoic acid, 99%

MDL
MFCD00002539
EINECS
218-682-5

Chemical Properties

Formula
C13H10O3
Formula Weight
214.22
Melting point
160-164°
Storage & Sensitivity
Ambient temperatures.
Solubility
Very faint turbidity in hot methanol.

Applications

4-Phenoxybenzoic acid can block DNA binding of the human papillomarvirus (HPV) E2 protein. It is employed as an intermediate of Sitafloxacin, which is a fluoroquinolone antibiotic that shows promise in the treatment of Buruli ulcer.

Notes

Store away from oxidizing agents and bases. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Mikaela Nichkova.; Dosi Dosev.; Shirley J Gee.; Bruce D Hammock.; Ian M Kennedy. Microarray immunoassay for phenoxybenzoic acid using polymer encapsulated Eu:Gd2O3 nanoparticles as fluorescent labels.Anal Chem.,2005,77(21), 6864-6873.

Hajduk PJ.; Dinges J.; Miknis GF.; Merlock M.; Middleton T.; Kempf DJ.; Egan DA.; Walter KA.; Robins TS.; Shuker SB.; Holzman TF.; Fesik SW. NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein.J Med Chem.,1997,40(20), 3144-50.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2212463
Harmonized Tariff Code
2918.99
TSCA
Yes

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