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68-41-7 - D-Cycloserine, 98+% - (R)-(+)-4-Amino-3-isoxazolidinone - A18000 - Alfa Aesar

A18000 D-Cycloserine, 98+%

CAS Number
68-41-7
Synonyms
(R)-(+)-4-Amino-3-isoxazolidinone

Size Price ($) Quantity Availability
1g 51.20
5g 197.00
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D-Cycloserine, 98+%

MDL
MFCD00005353
EINECS
200-688-4

Chemical Properties

Formula
C3H6N2O2
Formula Weight
102.09
Melting point
137° dec.
Sensitivity
Air Sensitive
Solubility
Soluble in water. Slightly soluble in methanol and propylene glycol. Insoluble in chloroform and ether.

Applications

Cycloserine is an amino acid analog antibiotic used for the treatment of tuberculosis and rarely used for the treatment of noninfectious diseases. It acts as a competitive inhibitor of D-alanine during peptidoglycan synthesis. It inhibits bacterial cell wall biosynthesis and prevents the conversion of D-Alanine to L-Alanine.

Notes

Air Sensitive. Store in cool place. Incompatible with strong oxidizing agents.

Literature References

Philbert, J.; Beeske, S.; Belzung, C.; Griebel, G. The CRF1 receptor antagonist SSR125543 prevents stress-induced long-lasting sleep disturbances in a mouse model of PTSD: Comparison with paroxetine and d-cycloserine. Behav Brain Res 2015, 279, 41-46.

Hofmann, S. G.; Carpenter, J. K.; Otto, M. W.; Rosenfield, D.; Smits, J. A. J.; Pollack, M. H. Dose timing of d-cycloserine to augment cognitive behavioral therapy for social anxiety: Study design and rationale. Contemp. Clin. Trials 2015, 43, 223-230.

Other References

Merck
14,2751
Beilstein
80798
Harmonized Tariff Code
2941.90
TSCA
No
RTECS
NY2975000

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