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3-Hydroxyflavone is a reactant involved in studies of photochemically-induced dioxygenase-type CO-release reactivity; phase-transfer protection and deprotection of hydroxychromones; and O-methylation with di-Me carbonate. As a reactant it is involved in the synthesis of biologically active molecules including 2-chloropyridine derivatives for studies of antitumor agents and telomerase inhibitors; dihydrochromenopyrazines and chromenoquinoxalines. It is also involved in studies of its electrochemical properties using voltammetric methodologies.
Katarzyna Grubel; Brynna J.Laughlin; Thora R.Maltais; Rhett C.Smith; Atta M.Arif, Lisa M.Berreau. Photochemically-induced dioxygenase-type CO-release reactivity of group 12 metal flavonolate complexes. Chemical Communications. 2011, 47,(37), 10431-10433.
Xin-Hua Liu; Hui-Feng Liu; Xu Shen; Bao-An Song; Pinaki S.Bhadury; Hai-Liang Zhu; Jin-Xing Liu; Xing-Bao Qi. Synthesis and molecular docking studies of novel 2-chloro-pyridine derivatives containing flavone moieties as potential antitumor agents. Bioorganic & Medicinal Chemistry Letters. 2010, 20,(14), 4163-4167.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.