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2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.
Kiyoshi Okuyama.; Susumu Shibuya.; Tomoki Hamamoto.; Toshitada Noguchi. Enzymatic synthesis of 2'-deoxyguanosine with nucleoside deoxyribosyltransferase-II.Biosci Biotechnol Biochem.2003,67(5), 989-995.
S Phadtare.; J Zemlicka. Synthesis and biological properties of 9-(trans-4-hydroxy-2-buten-1-yl)adenine and guanine: open-chain analogues of neplanocin A.J Med Chem.1987,30(2), 437-440.
Hazard Statements: H315-H319-H335-H360
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May damage fertility or the unborn child.
Precautionary Statements: P201-P202-P261-P264b-P271-P280i-P281-P302+P352-P304+P340-P305+P351+P338-P308+P313-P332+P313-P337+P313-P362-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear eye/face protection. Use personal protective equipment as required. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF exposed or concerned: Get medical advice/attention. If skin irritation occurs: If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant