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22381-54-0 - 2-(p-Toluenesulfonyl)ethanol, 98% - 2-(4-Methylphenylsulfonyl)ethanol - 2-(p-Tosyl)ethanol - A18249 - Alfa Aesar

A18249 2-(p-Toluenesulfonyl)ethanol, 98%

CAS Number
22381-54-0
Synonyms
2-(4-Methylphenylsulfonyl)ethanol
2-(p-Tosyl)ethanol

Size Price ($) Quantity Availability
1g 34.90
5g 86.60
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2-(p-Toluenesulfonyl)ethanol, 98%

MDL
MFCD00041757
EINECS
000-000-0

Chemical Properties

Formula
C9H12O3S
Formula Weight
200.26
Melting point
50-53°
Boiling Point
178-181°/0.2mm
Solubility
Slightly soluble in water.

Applications

2-(p-Toluenesulfonyl)ethanol is used as an organic chemical synthesis intermediate.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

Emanuel H.F.Escher; Helene Robert; Domenico C.Regoli; Serge A.St. Pierre. Photoaffinity labeling of the angiotensin II receptor. 1. Synthesis and biological activities of the labeling peptides. J. Med. Chem. 1978, 21,(9), 860-864.

 

Reagent for protection of the carboxyl group as its 2-(p-toluenesulfonyl)ethyl (Tse) [2-(4-methylphenylsulfonyl)ethyl (Mpse)] ester, e.g. by DCC coupling. The Tse group is useful for carboxyl protection of Boc amino acids in peptide synthesis, since it is stable to the acidic conditions used for Boc cleavage, but readily cleaved by mild base, e.g. dilute NaOH or Na2CO3 in dioxan-water: J. Chem. Soc.(C)., 2612 (1968). It can also be cleaved by non-aqueous bases, e.g. DBN: J. Chem. Soc., Chem. Commun., 1031 (1972), DBU: Tetrahedron Lett., 25, 2163 (1984), or TBAF in THF: Chem. Lett., 1595 (1987).

Other References

Beilstein
1961132
Harmonized Tariff Code
2930.90
TSCA
Yes

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