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A18279 2,3,5,6-Tetramethylpyrazine, 98+%

CAS Number
1124-11-4
Synonyms

Stock No. Size Price ($) Quantity Availability
A18279-14 25g 40.00
A18279-22 100g 130.00
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2,3,5,6-Tetramethylpyrazine, 98+%

MDL
MFCD00006146
EINECS
214-391-2

Chemical Properties

Formula
C8H12N2
Formula Weight
136.20
Melting point
83-86°
Boiling Point
190°
Density
1.08
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in water (4 g/L at 20°C).

Applications

2,3,5,6-Tetramethylpyrazine is an anti-inflammatory compound isolated from the fermented food natto. It demonstrated in vivo nootropic activity in rats. It is useful in the treatment of several disorders such as asthma, heart failure, rhinitis and urinary incontinence. It is a flavor ingredient of tobacco. It forms cocrystal with 4-hydroxybenzoic acid which exhibits supramolecular synthon polymorphism.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

B.R.Sreekanth; Peddy Vishweshwar; K.Vyas. Supramolecular synthon polymorphism in 2 : 1 co-crystal of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine. Chemical Communications. 2007, 23,2375-2377.

 

Wei Wu; Xiao Yu; Xiao-Ping Luo; Shu-Hua Yang; Dong Zheng. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behavioural Brain Research. 2013, 253,212-216.

Has been used as a component of a buffer to control the acid-catalyzed ring-opening of epoxides: J. Chem. Soc., Perkin 2, 1309 (1972).

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P264b-P270-P301+P312-P330-P501c

Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
113100
Harmonized Tariff Code
2933.99
TSCA
Yes
RTECS
UQ3905000

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