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1124-11-4 - 2,3,5,6-Tetramethylpyrazine, 98+% - A18279 - Alfa Aesar

A18279 2,3,5,6-Tetramethylpyrazine, 98+%

CAS Number
1124-11-4
Synonyms

Size Price ($) Quantity Availability
25g 39.04
100g 117.00
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2,3,5,6-Tetramethylpyrazine, 98+%

MDL
MFCD00006146
EINECS
214-391-2

Chemical Properties

Formula
C8H12N2
Formula Weight
136.20
Melting point
83-86°
Boiling Point
190°
Density
1.08
Solubility
Soluble in water (4 g/L at 20°C).

Applications

2,3,5,6-Tetramethylpyrazine is an anti-inflammatory compound isolated from the fermented food natto. It demonstrated in vivo nootropic activity in rats. It is useful in the treatment of several disorders such as asthma, heart failure, rhinitis and urinary incontinence. It is a flavor ingredient of tobacco. It forms cocrystal with 4-hydroxybenzoic acid which exhibits supramolecular synthon polymorphism.

Notes

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

B.R.Sreekanth; Peddy Vishweshwar; K.Vyas. Supramolecular synthon polymorphism in 2 : 1 co-crystal of 4-hydroxybenzoic acid and 2,3,5,6-tetramethylpyrazine. Chemical Communications. 2007, 23,2375-2377.

 

Wei Wu; Xiao Yu; Xiao-Ping Luo; Shu-Hua Yang; Dong Zheng. Tetramethylpyrazine protects against scopolamine-induced memory impairments in rats by reversing the cAMP/PKA/CREB pathway. Behavioural Brain Research. 2013, 253,212-216.

Has been used as a component of a buffer to control the acid-catalyzed ring-opening of epoxides: J. Chem. Soc., Perkin 2, 1309 (1972).

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
113100
Harmonized Tariff Code
2933.99
TSCA
Yes
RTECS
UQ3905000

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