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A18305 (1-Ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate, 98%

CAS Number
(1-Carboethoxycyclopropyl)triphenylphosphonium tetrafluoroborate
Fuchs' Reagent

Stock No. Size Price ($) Quantity Availability
A18305-03 1g 28.20
A18305-06 5g 113.00
A18305-14 25g 465.00
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(1-Ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate, 98%


Chemical Properties

Formula Weight
Melting point
Storage & Sensitivity
Ambient temperatures.
Slightly soluble in water.


(1-Ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate is used as pharmaceutical intermediate.


Stable under recommended storage conditions. Incompatible with oxidizing agents.

Literature References

Seung Won Chung; Mark S.Plummer; Laura A.McAllister; Robert M.OliverIII; Joseph A.Abramite; Yue Shen; Jianmin Sun; Daniel P.Uccello; Joel T.Arcari; Loren M.Price; Justin I.Montgomery. Org. Lett. 2011, 13,(19), 5338-5341.


Valuable intermediate for cycloalkenylation of compounds containing a nucleophilic center and a carbonyl group. Nucleophilic ring-opening of the cyclopropyl ring is followed by intramolecular Wittig reaction (see Appendix 1) of the intermediate carbonyl-phosphorane; e.g., with ß-keto esters, cyclopentenes are formed: J. Am. Chem. Soc., 96, 1607 (1974):

With 2-formylcyclohexanones, spirocyclopentenes are obtained: J. Am. Chem. Soc., 99, 7307 (1977). Na carboxylates give 2,3-dihydrofurans: Tetrahedron Lett., 4353 (1975), and thiolcarboxylates give dihydrothiophenes, readily aromatized to thiophenes with DDQ: J. Chem. Soc., Perkin 1, 2403 (1994):

Cyclic imides e.g. Succinimide, A13503, give bridgehead lactams: Liebigs Ann. Chem., 521 (1983); for reaction scheme, see Glutarimide, L00968.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

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