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4-(Trifluoromethyl)aniline hydrochloride is used in the synthesis of 2-(4-((6-Chloro-2-quinoxalinyl)oxy)phenoxy)-N-(4-(trifluoromethyl)phenyl)propanamide. It is also used to produce N-(p-trifluoromethylphenyl)phosphoramidic dichloride.
Chun-Yen Chen.; Hui-Chang Lin.; Yu-Ying Huang.; Kun-Lung Chend.; Jiann-Jyh Huang.; Mou-Yung Yeh.; Fung Fuh Wong. One-flask transformation of isocyanates and isothiocyanates to guanidines hydrochloride by using sodium bis(trimethylsilyl)amide. Tetrahedron. 2010, 66 (10), 1892-1897.
Thomas-Xavier Métro.; Julien Bonnamour.; Thomas Reidon.; Jordi Sarpoulet.; Jean Martineza.; Frédéric Lamaty. Mechanosynthesis of amides in the total absence of organic solvent from reaction to product recovery. Chem. Commun. 2012, 48 (96), 11781-11783.
Hazard Statements: H301-H315-H319-H335-H373
Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause damage to organs through prolonged or repeated exposure.
Precautionary Statements: P260-P280a-P301+P310a-P305+P351+P338-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF SWALLOWED: Immediately call a POISON CENTER/doctor IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.