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A18400 7-Amino-4-(trifluoromethyl)coumarin, 99%

CAS Number
53518-15-3
Synonyms
Coumarin 151

Stock No. Size Price ($) Quantity Availability
A18400-01 0.25g 28.80
A18400-03 1g 82.80
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7-Amino-4-(trifluoromethyl)coumarin, 99%

MDL
MFCD00006858
EINECS
258-599-1

Chemical Properties

Formula
C10H6F3NO2
Formula Weight
229.16
Melting point
222-223°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.

Applications

7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Literature References

Eugene R. Bissell.; Alexander R. Mitchell.; Robert E. Smith. Synthesis and chemistry of 7-amino-4-(trifluoromethyl)coumarin and its amino acid and peptide derivatives. J. Org. Chem. 1980, 45 (12), 2283-2287.

Chen-Shane Chu.; Yu-Lung Lo. Ratiometric fiber-optic oxygen sensors based on sol-gel matrix doped with metalloporphyrin and 7-amino-4-trifluoromethyl coumarin. Sensors and Actuators B: Chemical. 2008, 134 (2), 711-717.

Used in synthesis of substrates for fluorometric assay of proteolytic enzymes: Anal. Biochem ., 70, 258 (1976).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335-H500

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May form combustible dust concentrations in air

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
4456797
Harmonized Tariff Code
2932.20
TSCA
Yes

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