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53518-15-3 - 7-Amino-4-(trifluoromethyl)coumarin, 99% - Coumarin 151 - A18400 - Alfa Aesar

A18400 7-Amino-4-(trifluoromethyl)coumarin, 99%

CAS Number
53518-15-3
Synonyms
Coumarin 151

Size Price ($) Quantity Availability
0.25g 27.19
1g 78.07
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7-Amino-4-(trifluoromethyl)coumarin, 99%

MDL
MFCD00006858
EINECS
258-599-1

Chemical Properties

Formula
C10H6F3NO2
Formula Weight
229.16
Melting point
222-223°
Solubility
Soluble in dimethyl sulfoxide (25 mg/ml), dimethyl formamide (25 mg/ml), and methanol (25 mg/ml). Insoluble in water.

Applications

7-Amino-4-(trifluoromethyl)coumarin is used in the synthesis of substrates for the fluorometric assay of proteolytic enzymes in biological fluids. It is suitable as laser dye.

Notes

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Literature References

Eugene R. Bissell.; Alexander R. Mitchell.; Robert E. Smith. Synthesis and chemistry of 7-amino-4-(trifluoromethyl)coumarin and its amino acid and peptide derivatives. J. Org. Chem. 1980, 45 (12), 2283-2287.

Chen-Shane Chu.; Yu-Lung Lo. Ratiometric fiber-optic oxygen sensors based on sol-gel matrix doped with metalloporphyrin and 7-amino-4-trifluoromethyl coumarin. Sensors and Actuators B: Chemical. 2008, 134 (2), 711-717.

Used in synthesis of substrates for fluorometric assay of proteolytic enzymes: Anal. Biochem ., 70, 258 (1976).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
4456797
Harmonized Tariff Code
2932.20
TSCA
Yes

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