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1670-81-1 - Indole-5-carboxylic acid, 98% - A18627 - Alfa Aesar

A18627 Indole-5-carboxylic acid, 98%

CAS Number
1670-81-1
Synonyms

Size Price ($) Quantity Availability
1g 35.30
5g 115.00
25g 498.00
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Indole-5-carboxylic acid, 98%

MDL
MFCD00005678
EINECS
216-799-6

Chemical Properties

Formula
C9H7NO2
Formula Weight
161.16
Melting point
208-212°
Solubility
Soluble in ethanol (50 mg/ml), dimethyl sulfoxide and methanol.

Applications

Indole-5-carboxylic acid is the suitable reagent used to study the intermolecular excited state proton transfer in indole-2-carboxylic acid and indole-5-carboxylic acid in various solvents in acidic, basic, and neutral media by steady state and time resolved fluorescence spectroscopy. It may be used in the electrochemical synthesis of poly(indole-5-carboxylic acid) (PICA) films. Also used as reactant for preparation of tryptophan dioxygenase inhibitors pyridyl-ethenyl-indoles, as potential anticancer immunomodulators, synthesis of indirubin derivatives and amide conjugates with ketoprofen, as inhibitors of Gli1-mediated transcription in Hedgehog pathway.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Literature References

Eduard Dolusi? et. al. Tryptophan 2,3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl)ethenyl)indoles as potential anticancer immunomodulators. Journal of medicinal and pharmaceutical chemistry, 2011, 54 (15), 5320-5334.

Mikaël Brasse; Jonathan A Ellman; Robert G Bergman. A facile, metal- and solvent-free, autoxidative coupling of quinolines with indoles and pyrroles. Chemical Communications, 2011, 47 (17), 5019-5021.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
124391
Harmonized Tariff Code
2933.99
TSCA
No

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