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A18696 1,4-Benzodioxane-6-carboxaldehyde, 99%

CAS Number
29668-44-8
Synonyms
3,4-(Ethylenedioxy)benzaldehyde

Stock No. Size Price ($) Quantity Availability
A18696-03 1g 28.30
A18696-06 5g 86.20
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1,4-Benzodioxane-6-carboxaldehyde, 99%

MDL
MFCD00010092
EINECS
249-763-3

Chemical Properties

Formula
C9H8O3
Formula Weight
164.16
Melting point
48-52°
Boiling Point
104-106°/15mm
Flash Point
>110°(230°F)
Storage & Sensitivity
Air Sensitive. Ambient temperatures.
Solubility
Solubility in methanol is almost transparent.

Applications

1,4-Benzodioxan-6-carboxaldehyde finds its uses as building block in the synthesis of tetrahydroisoquinolinones, in the preparation of benzofuran analog, a potential inhibitor of CAMP-specific phosphodiesterase type IV, in the synthesis of (5Z)-5-(2,3-dihydro-1,4-benzodioxan-6-ylmethylene)-1-methyl-2-thioxoimidazolidin-4-one. It was screened as a fragment for inhibitors of PDEA using enthalpy arrays and X-ray crystallography. 1,4-Benzodioxane-6-carboxaldehyde have also been used as an intermediate in the synthesis of a new class of Dopamine D3 and D4 receptor antagonists.

Notes

Store away from air, oxidizing agents and bases. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Stafford JA, et al. Structure-activity relationships involving the catechol subunit of rolipram.Bioorg. Med. Chem. Lett.1994,4(15), 1855-60.

M Lebl. New technique for high-throughput synthesis.Bioorg Med Chem Lett.1999,9(9), 1305-1310.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c

Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Harmonized Tariff Code
2932.99
TSCA
No

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