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A18796 (-)-Cinchonidine, 99% (total base), may cont. up to 5% quinine

CAS Number
485-71-2
Synonyms

Stock No. Size Price ($) Quantity Availability
A18796-14 25g 58.70
A18796-22 100g 213.00
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(-)-Cinchonidine, 99% (total base), may cont. up to 5% quinine

MDL
MFCD00006783
EINECS
207-622-3

Chemical Properties

Formula
C19H22N2O
Formula Weight
294.39
Melting point
201-206°
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Insoluble in water. Soluble in alcohol and chloroform.

Applications

It finds its uses as an antimalarial compound. It is a lysosomotropic agent, inhibits Plasmodium falciparum, interferes with ferriprotoporphyrin formation and is a weak SERT inhibitor.

Notes

Light Sensitive. Store away from oxidizing agents and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Barennes H.; Verdier F.; Clavier F.; Pussard E. Pharmacokinetics of Quinimax suppositories in children with malaria: preliminary study.Clin. Drug Invest.;1999,17287-291.

J M Karle.; I L Karle.; L Gerena and W K Milhous Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum.Antimicrob. Agents Chemother.1992,36(7), 1538-1544.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H317

Harmful if swallowed. May cause an allergic skin reaction.

Precautionary Statements: P261-P264b-P270-P272-P280g-P301+P312-P302+P352-P330-P333+P313-P363-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. Rinse mouth. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,2286
Beilstein
89690
Harmonized Tariff Code
2939.20
TSCA
Yes
RTECS
GD3500000

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