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485-71-2 - (-)-Cinchonidine, 99% (total base), may cont. up to 5% quinine - A18796 - Alfa Aesar

A18796 (-)-Cinchonidine, 99% (total base), may cont. up to 5% quinine

CAS Number
485-71-2
Synonyms

Size Price ($) Quantity Availability
25g 60.60
100g 208.00
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(-)-Cinchonidine, 99% (total base), may cont. up to 5% quinine

MDL
MFCD00006783
EINECS
207-622-3

Chemical Properties

Formula
C19H22N2O
Formula Weight
294.39
Melting point
201-206°
Sensitivity
Light Sensitive
Solubility
Insoluble in water. Soluble in alcohol and chloroform.

Applications

It finds its uses as an antimalarial compound. It is a lysosomotropic agent, inhibits Plasmodium falciparum, interferes with ferriprotoporphyrin formation and is a weak SERT inhibitor.

Notes

Light Sensitive. Store away from oxidizing agents and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Barennes H.; Verdier F.; Clavier F.; Pussard E. Pharmacokinetics of Quinimax suppositories in children with malaria: preliminary study.Clin. Drug Invest.;1999,17287-291.

J M Karle.; I L Karle.; L Gerena and W K Milhous Stereochemical evaluation of the relative activities of the cinchona alkaloids against Plasmodium falciparum.Antimicrob. Agents Chemother.1992,36(7), 1538-1544.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H334-H317

Harmful if swallowed. May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction.

Precautionary Statements: P284-P261-P280g-P342+P311a-P301+P312a-P501a

Wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves. If experiencing respiratory symptoms: IF SWALLOWED: Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2286
Beilstein
89690
Harmonized Tariff Code
2939.20
TSCA
Yes
RTECS
GD3500000

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