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52509-14-5 - (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide, 98% - A18882 - Alfa Aesar

A18882 (1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide, 98%

CAS Number
52509-14-5
Synonyms

Size Price ($) Quantity Availability
10g 59.10
50g 206.00
250g 873.00
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(1,3-Dioxolan-2-ylmethyl)triphenylphosphonium bromide, 98%

MDL
MFCD00011966
EINECS
257-977-3

Chemical Properties

Formula
C22H22BrO2P
Formula Weight
429.30
Melting point
186-189°
Sensitivity
Hygroscopic
Solubility
Soluble in water (20°C).

Applications

It finds its applications as a reagent for Wittig olefinations with introduction of a 1,3-dioxolane moiety. It is applied as a reactant for the preparation of a ratiometric fluorescent probe for specific detection of cysteine over homocysteine and glutathione, for microwave-assisted synthesis of KN-93 as inhibitor of calmodulin kinase II, for the preparation of fluorinated spirobenzofuran piperidines as s1 receptor ligands, in the synthesis and antitumor agents, in regio-selective preparation of indole derivatives via rhodium-catalyzed domino hydroformylation/indolization.

Notes

Hygroscopic. Store away from water/moisture and oxidizing agents. Store under inert gas. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Lin Yuan.; Weiying Lin.; Yueting Yang. A ratiometric fluorescent probe for specific detection of cysteine over homocysteine and glutathione based on the drastic distinction in the kinetic profiles.Chem. Commun. (Camb).2011,47(22), 6275-6277.

Eva Große Maestrup.; Christian Wiese.; Dirk Schepmann.; Peter Brust.; Bernhard Wünsch. Synthesis, pharmacological activity and structure affinity relationships of spirocyclic ?1 receptor ligands with a (2-fluoroethyl) residue in 3-position.Bioorg Med Chem.2011,19(1), 393-405.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Harmonized Tariff Code
2932.99
TSCA
No

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