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80-08-0 - 4,4'-Diaminodiphenyl sulfone, 98% - 4-Aminophenyl sulfone - Bis(4-aminophenyl) sulfone - A18976 - Alfa Aesar

A18976 4,4'-Diaminodiphenyl sulfone, 98%

CAS Number
80-08-0
Synonyms
4-Aminophenyl sulfone
Bis(4-aminophenyl) sulfone

Size Price ($) Quantity Availability
100g 41.30
500g 122.40
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4,4'-Diaminodiphenyl sulfone, 98%

MDL
MFCD00007887
EINECS
201-248-4

Chemical Properties

Formula
C12H12N2O2S
Formula Weight
248.30
Melting point
175-178°
Solubility
Insoluble in water. Solubility in hot methanol is almost transparent. Soluble in DMSO, ethanol and acetone.

Applications

It is active against a wide range of bacteria, but is mainly employed for its actions against Mycobacterium leprae, being used as part of multidrug regimens in the treatment of all forms of leprosy. It is a second-line medication for the treatment and prevention of Pneumocystis pneumonia and for the prevention of toxoplasmosis in those who have poor immune function. Additionally, it has been used for acne as well as other skin conditions. Moreover it is employed as an anti-inflammatory drug, anti-infective drug, a leprostatic drug and an antimalarial drug.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Patel AP, Patil AS. Dapsone for immune thrombocytopenic purpura in children and adults.Therapeutic drug monitoring.2014,36(2), 261-263.

B.L. Maloff, et al. Dapsone inhibits LTB4 binding and bioresponse at the cellular and physiologic levels.Eur. J. Pharmacol.1988158(1-2), 85-89.

GHS Hazard and Precautionary Statements

Hazard Statements: H302

Harmful if swallowed.

Precautionary Statements: P261

Avoid breathing dust/fume/gas/mist/vapours/spray.

Other References

Merck
14,2822
Beilstein
788055
Harmonized Tariff Code
2930.90
TSCA
Yes
RTECS
BY8925000

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