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56613-80-0 - (R)-(-)-2-Phenylglycinol, 98% - (R)-(-)-2-Amino-2-phenylethanol - H-D-Phg-ol - A19030 - Alfa Aesar

A19030 (R)-(-)-2-Phenylglycinol, 98%

CAS Number
56613-80-0
Synonyms
(R)-(-)-2-Amino-2-phenylethanol
H-D-Phg-ol

Size Price ($) Quantity Availability
1g 23.04
5g 68.16
25g 235.20
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(R)-(-)-2-Phenylglycinol, 98%

MDL
MFCD00008062
EINECS
260-287-5

Chemical Properties

Formula
C8H11NO
Formula Weight
137.18
Melting point
76-78°
Sensitivity
Air Sensitive
Solubility
Slightly soluble in water.

Applications

Amino alcohol used to prepare a chiral imine or oxazolidine from ethyl trifluoropyruvate. These intermediates were then employed in a synthesis of both enantiomers of α-trifluoromethylproline. Chiral β-amino alcohol used as a synthetic building block.

Notes

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Literature References

Grégory Chaume et. al. Straightforward synthesis of (S)- and (R)-alpha-trifluoromethyl proline from chiral oxazolidines derived from ethyl trifluoropyruvate.. Organic Letters. 2006, 8 (26), 6123-6126.

Amberley S. Anslow,; Laurence M. Harwood,; Helen Phillips,; David Watkib .Development of a chiral stabilised azomethine ylid. A chiral relay system.. Tetrahedron: Asymmetry. year of publication , 2 (3), 169-172.

Condensation with glutaraldehyde gives a useful intermediate in asymmetric synthesis of alkaloids: Org. Synth. Coll., 9, 176 (1998):

Starting material for the enantioselective synthesis of 2,6-disubstituted piperazines: Synthesis, 833 (1996), and for chiral ɑ-amino phosphonates: Org. Synth., 75, 19 (1997).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
2935848
Harmonized Tariff Code
2922.19
TSCA
No

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