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3-chloro-4-trifluoromethylanilinewas prepared in two steps by reaction of trifluoromethylcopper with 3-chloro-4-iodonitrobenzene.
R Kapil. Notes- The Nitration of 3-Chloro-4-iodonitrobenzene . J. Org. Chem. 1960, volume (5), 841-841.
Jonathan D. Bloom,; Martin J. DiGrandi,; Russell G. Dushin,; Kevin J. Curran. Thiourea inhibitors of herpes viruses. part 1: bis-(aryl)thiourea inhibitors of CMV. Bioorganic & Medicinal Chemistry Letters. 2003,, 13 (17), 2929-2932.
Hazard Statements: H302+H312+H332-H315-H319-H335
Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant