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A19450 2-Bromo-6-methoxynaphthalene, 98%

CAS Number
5111-65-9
Synonyms
2-Methoxy-6-bromonaphthalene

Stock No. Size Price ($) Quantity Availability
A19450-09 10g 43.60
A19450-18 50g 166.00
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2-Bromo-6-methoxynaphthalene, 98%

MDL
MFCD00004062
EINECS
225-837-0

Chemical Properties

Formula
C11H9BrO
Formula Weight
237.10
Melting point
105-110°
Boiling Point
160-164°/3mm
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in DMSO. Insoluble in water.

Applications

2-Bromo-6-methoxynaphthalene is used in the synthesis of nabumetone [4-(6-methoxy-2-naphthalenyl)-2-butanone] by Heck reaction.

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Howard Alper.; Nathalie Hamel. Asymmetric synthesis of acids by the palladium-catalyzed hydrocarboxylation of olefins in the presence of (R)-(-)- or (S)-(+)-1,1'-binaphthyl-2,2'-diyl hydrogen phosphate. J. Am. Chem. Soc. 1990, 112, (7), 2803-2804.

Stephen W. Wright.; David L. Hageman.; Lester D. McClure. Fluoride-Mediated Boronic Acid Coupling Reactions. J. Org. Chem. 1994, 59, (20), 6095-6097.

Undergoes highly efficient, phosphine-free Suzuki coupling reactions with arylboronic acids in water, catalyzed by Pd(II) acetate in the presence of TBAB and potassium carbonate: J. Org. Chem., 62, 7170 (1997).

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
2043874
Harmonized Tariff Code
2909.30
TSCA
No

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