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A19676 4-Fluoro-3-nitrobenzotrifluoride, 97%

CAS Number
367-86-2
Synonyms
2-Fluoro-5-(trifluoromethyl)nitrobenzene

Stock No. Size Price ($) Quantity Availability
A19676-14 25g 26.30
A19676-22 100g 60.80
A19676-36 500g 210.00
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4-Fluoro-3-nitrobenzotrifluoride, 97%

MDL
MFCD00007059
EINECS
206-702-5

Chemical Properties

Formula
C7H3F4NO2
Formula Weight
209.10
Boiling Point
91-92°/15mm
Flash Point
90°(194°F)
Density
1.494
Refractive Index
1.4620
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

4-Fluoro-3-nitrobenzotrifluoride is used in the pre-column derivatization technique for HPLC with UV/VIS spectrophotometric detection of polyamines. It may be used as derivatization reagent for the HPLC determination of polyamines. It was also used in the synthesis of 2-nitro-4-trifluoromethylphenylhydrazine, derivatization reagent for 1,2-diol compounds and oxo-steroids. • [3-(2-nitro-4-trifluoromethylphenyl)aminophenyl]dihydroxyborane, derivatization reagent for 1,2-diol compounds and oxo-steroids3 • 1-(3-chlorophenyl)-5-trifluoromethyl-3-hydrobenzimidazol-2-one

Notes

Store away from strong oxidizing agents. Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Literature References

Jorgen Vessman.; Signhild Stromberg. Determination of tranexamic acid in biological material by electron capture gas chromatography after direct derivatization in an aqueous medium. Anal. Chem. 1977, 49, (3), 369-373

 

J. T. Gerig.; J. D. Reinheimer. Modification of human serum albumin with trifluoromethyl-substituted aryl halides and sulfonates J. Am. Chem. Soc. 1975, 97, (1), 168-173

 

The nitro-group can be selectively displaced with KF in sulfolane, in the presence of phthaloyl chloride as a nitrite trap: J. Org. Chem., 56, 6406 (1991).

GHS Hazard and Precautionary Statements

Hazard Statements: H226-H315-H319-H335

Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210-P233-P235-P240-P241-P242-P243-P261-P264b-P271-P280-P303+P361+P353-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P363-P370+P378q-P501c

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Wash contaminated clothing before reuse. In case of fire: Use CO2, dry chemical, or foam Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1880508
Hazard Class
3
Packing Group
III
Harmonized Tariff Code
2904.99
TSCA
No

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