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It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.
Tinny T.; Chacko AJ.; Jose S. Formulation development and statistical optimization of chronotherapeutic tablets of indometacin.Drug Dev. Ind. Pharm.2013,39(9), 1357-1363.
Han L, et al. Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of e-cadherin in pancreatic cancer cells. Current medicinal chemistry.2013,20(33), 4142-4152.
Hazard Statements: H300-H317-H360FD
Fatal if swallowed. May cause an allergic skin reaction. May damage fertility. Suspected of damaging the unborn child. May damage fertility. May damage the unborn child.
Precautionary Statements: P201-P202-P264b-P270-P272-P280g-P281-P301+P310-P302+P352-P308+P313-P330-P333+P313-P363-P501c
Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation or rash occurs: Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant