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A19910 Indomethacin, 98%

CAS Number
53-86-1
Synonyms
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

Stock No. Size Price ($) Quantity Availability
A19910-06 5g 44.00
A19910-14 25g 154.00
A19910-22 100g 469.00
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Indomethacin, 98%

MDL
MFCD00057095
EINECS
200-186-5

Chemical Properties

Formula
C19H16ClNO4
Formula Weight
357.8
Melting point
158-161°
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubility
Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.

Applications

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

Notes

Store away from oxidizing agents, strong bases and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Tinny T.; Chacko AJ.; Jose S. Formulation development and statistical optimization of chronotherapeutic tablets of indometacin.Drug Dev. Ind. Pharm.2013,39(9), 1357-1363.

Han L, et al. Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of e-cadherin in pancreatic cancer cells. Current medicinal chemistry.2013,20(33), 4142-4152.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H317-H360FD

Fatal if swallowed. May cause an allergic skin reaction. May damage fertility. Suspected of damaging the unborn child. May damage fertility. May damage the unborn child.

Precautionary Statements: P201-P202-P261-P264b-P270-P272-P280g-P281-P301+P310-P302+P352-P308+P313-P330-P333+P313-P363-P501c

Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. Use personal protective equipment as required. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF exposed or concerned: Get medical advice/attention. Rinse mouth. If skin irritation or rash occurs: Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Merck
14,4968
Beilstein
497341
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2933.99
TSCA
Yes
RTECS
NL3500000

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