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53-86-1 - Indomethacin, 98% - 1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid - A19910 - Alfa Aesar

A19910 Indomethacin, 98%

CAS Number
53-86-1
Synonyms
1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid

Size Price ($) Quantity Availability
5g 41.00
25g 149.00
100g 464.00
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Indomethacin, 98%

MDL
MFCD00057095
EINECS
200-186-5

Chemical Properties

Formula
C19H16ClNO4
Formula Weight
357.8
Melting point
158-161°
Solubility
Soluble in acetone (40 mg/mL - clear, yellow solution), ethanol (20 mg/mL), ether, castor oil; Soluble in chloroform (50 mg/mL - clear, yellow, extremely viscous solution); decomposed by strong alkali but stable in neutral or slightly acidic media; insoluble in water.

Applications

It is a non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis. It finds its application as gout suppressant, non-steroidal anti-inflammatory drug and analgesic. It also plays many biological roles. Additionally, Indomethacin displays adipogenic actions via binding and activation of PPARγ (peroxisome proliferator-activated receptor γ), a ligand-activated transcription factor known to play an important role in adipogenesis.

Notes

Store away from oxidizing agents, strong bases and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Tinny T.; Chacko AJ.; Jose S. Formulation development and statistical optimization of chronotherapeutic tablets of indometacin.Drug Dev. Ind. Pharm.2013,39(9), 1357-1363.

Han L, et al. Indometacin ameliorates high glucose-induced proliferation and invasion via modulation of e-cadherin in pancreatic cancer cells. Current medicinal chemistry.2013,20(33), 4142-4152.

GHS Hazard and Precautionary Statements

Hazard Statements: H300-H341

Fatal if swallowed. Suspected of causing genetic defects.

Precautionary Statements: P201-P280-P301+P310a-P308+P313-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4968
Beilstein
497341
Hazard Class
6.1
Packing Group
II
Harmonized Tariff Code
2933.99
TSCA
Yes
RTECS
NL3500000

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