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4241-27-4 - 3-Cyano-6-methyl-2-pyridone, 98% - 3-Cyano-2-hydroxy-6-methylpyridine - 2-Hydroxy-6-methylnicotinonitrile - B20188 - Alfa Aesar

B20188 3-Cyano-6-methyl-2-pyridone, 98%

CAS Number
4241-27-4
Synonyms
3-Cyano-2-hydroxy-6-methylpyridine
2-Hydroxy-6-methylnicotinonitrile

Size Price ($) Quantity Availability
10g 49.50
50g 222.48
250g 720.80
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3-Cyano-6-methyl-2-pyridone, 98%

MDL
MFCD00006013
EINECS
224-202-5

Chemical Properties

Formula
C7H6N2O
Formula Weight
134.14
Melting point
ca 298° dec.
Solubility
Soluble in water at 20°C, 2.38 g/L.

Applications

3-Cyano-6-methyl-2(1H)-pyridinone is a reactant used in the synthesis of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. 3-It has also been used in the preparation of the N3?-pyridyl thiamine, a potent in vitro thiamine antagonist.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Allen A. Thomas, et al. Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.Bioorg Med Chem Lett.2008,18(6), 2206-2210.

Munakata M, et al. Construction of three-dimensional supramolecular coordination copper (I) compounds with channel structures hosting a variety of anions by changing the hydrogen-bonding mode and distances.J. Am. Chem. Soc.1996,118(13), 3117-24.

GHS Hazard and Precautionary Statements

Hazard Statements: H301-H315-H319-H335

Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P301+P310-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
120412
Harmonized Tariff Code
2933.39
TSCA
Yes

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