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Trimethyl borate is a useful reagent in organic synthesis. It is involved in the production of resins, waxes and paints and acts as a methylation agent. As a boron source, it is used to prepare flame retardants, anti-oxidants and corrosion inhibitors. It reacts with Grignard reagents followed by hydrolysis to prepare boronic acid. It is also used as a precursor of borate esters, which finds application in Suzuki coupling reaction. It is an intermediate in the preparation of sodium borohydride.
For an example of the low temperature reaction with Grignard reagents to give boronic acids., see: Org. Synth. Coll., 4, 68 (1963).
Bao, Z.; Zhang, W.; Cui, X.; Xu, J. Design, Optimization and Control of Extractive Distillation for the Separation of Trimethyl Borate-Methanol. Ind. Eng. Chem. Res. 2014, 53 (38), 14802-14814.
Chang, C. C.; Lee, K. Y.; Lee, H. Y.; Su, Y. H.; Her, L. J. Trimethyl borate and triphenyl borate as electrolyte additives for LiFePO4 cathode with enhanced high temperature performance. J. Power Sources 2012, 217, 524-529.
Hazard Statements: H225-H312-H370
Highly flammable liquid and vapour. Harmful in contact with skin. Causes damage to organs.
Precautionary Statements: P210-P233-P240-P243-P260-P264b-P270-P280-P302+P352-P312-P314-P362-P372-P374-P380-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Take precautionary measures against static discharge. Do not breathe dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. Call a POISON CENTER or doctor/physician if you feel unwell. Get medical advice/attention if you feel unwell. Take off contaminated clothing and wash before reuse. Explosion risk in case of fire. Fight fire with normal precautions from a reasonable distance. Evacuate area. Dispose of contents/ container to an approved waste disposal plant