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Dithranol was used as a matrix in MALDI TOF mass spectrometry measurements of sol-gel films for DNA microarray applications. It was also used as matrix in matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS) and liquid secondary ion-tandem mass spectrometry (LSI-MS/MS) for the analysis of synthetic polymers to generate values for the average mass and the mass of the end groups. It was also used in MALDI-MS for direct detection of condensed tannins in bark. It is successfully used for the treatment of psoriasis.
P Juhasz, C E Costello. Generation of large radical ions from oligometallocenes by matrix-assisted laser desorption ionization. Rapid Communications in Mass Spectrometry. 1993, 7 (5), 343-351.
Anthony T. Jackson; Keith R. Jennings; James H. Scrivens. Generation of average mass values and end group information of polymers by means of a combination of matrix-assisted laser desorption/ionization-mass spectrometry and liquid secondary ion-tandem mass spectrometry. Journal of the American Society for Mass Spectrometry. 1997, 8 (1), 76-85.
Hazard Statements: H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c
Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant