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5-(3-Pyridyl)-1H-tetrazole is used as a pharmaceutical intermediate. The Pyridine,3-(2H-tetrazol-5-yl)- acts as reactant with 1-(4-bromo-phenyl)-3-piperidino-propan-1-one, hydrochloride, and obtain the 1-(4-bromo-phenyl)-3-(5-pyridin-3-yl-tetrazol-2-yl)-propan-1-one. This reaction needs the solvent of dimethylformamide. The yield is 31%. In addition, this reaction should be taken for 8 hours at the temperature of 150°C.
H X Xue.; XS Wang.; LZ Wang.; RG Xiong. Hydrothermal preparation of novel Cd (II) coordination polymers employing 5-(4-pyridyl) tetrazolate as a bridging ligand. Inorg. Chem. 200241 ( 25), 6544-6546.
EK Moltzen.; H Pedersen.; KP Boegesoe. Bioisosteres of Arecoline: 1,2,3,6-Tetrahydro-5-pyridyl-Substituted and 3-Piperidyl-Substituted Derivatives of Tetrazoles and 1,2,3-Triazoles. Synthesis and Muscarinic Activity. J. Med. Chem. 199437 ( 24), 4085-4099.
Hazard Statements: H318
Causes serious eye damage.
Precautionary Statements: P280-P305+P351+P338-P310
Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Immediately call a POISON CENTER or doctor/physician.