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83-49-8 - Hyodeoxycholic acid, 96% - 3alpha,6alpha-Dihydroxy-5beta-cholan-24-oic acid - B20506 - Alfa Aesar

B20506 Hyodeoxycholic acid, 96%

CAS Number
83-49-8
Synonyms
3alpha,6alpha-Dihydroxy-5beta-cholan-24-oic acid

Size Price ($) Quantity Availability
5g 44.46
25g 153.47
100g 526.33
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Hyodeoxycholic acid, 96%

MDL
MFCD00003681
EINECS
201-483-2

Chemical Properties

Formula
C24H40O4
Formula Weight
392.59
Melting point
197-199°
Solubility
Solubility in methanol, very faint turbidity. Slightly soluble in alcohol, acetone, ether and very slightly soluble in chloroform.

Applications

It is the main acid constituent of hog bile, and for this reason it was used industrially as precursor for steroid synthesis before total synthesis became practical.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Sato H, et al. Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies.J. Med. Chem.2008,51(6), 1831-1841.

Shih DM, et al. Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice.FASEB J.2013,27(9), 3805-3817.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4857
Harmonized Tariff Code
2918.19
TSCA
No
RTECS
FZ2050000

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