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(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
AA Hardigree.; JL Epler. Comparative mutagenesis of plant flavonoids in microbial systems. Mutation Research/Genetic Toxicology. 197858 (2-3), 1109-1114.
LW Wattenberg.; MA Page.; JL Leong. Induction of increased benzpyrene hydroxylase activity by flavones and related compounds. Cancer Research. 196828 (1), 934-936.