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o-Toluene sulfonamide was mainly produced as a chemical intermediate for the production of saccharin. A mixture of o-Toluene sulfonamide with the p-isomer is used as a plasticizer for hot -melt adhesives, a chemical intermediate for fluorescent pigments and a chemical intermediate for plasticizer resins. (S080800). Studies suggest that o-Toluene sulfonamide has potential mutagenic activity.
JL Kacprzak. Determination of o-toluenesulfonamide in artificial sweeteners containing saccharin. Journal-Association of Official Analytical Chemists. 197861 (6), 1528-1532.
L Xu.; H Shu.; Y Liu.; S Zhang.; ML Trudell. Oxidative cyclization of N-alkyl-o-methyl-arenesulfonamides to biologically important saccharin derivatives. Tetrahedron. 200661 (6), 1528-1532.
Hazard Statements: H303-H315-H319-H351-H335
May be harmful if swallowed. Causes skin irritation. Causes serious eye irritation. Suspected of causing cancer. May cause respiratory irritation.
Precautionary Statements: P201-P261-P280-P305+P351+P338-P405-P501a
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.