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B20570 2-Mercapto-5-methoxybenzimidazole, 99%

CAS Number
37052-78-1
Synonyms
5-Methoxy-2-benzimidazolethiol
5-Methoxy-2-mercaptobenzimidazole

Stock No. Size Price ($) Quantity Availability
B20570-06 5g 24.80
B20570-14 25g 90.30
B20570-22 100g 344.00
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2-Mercapto-5-methoxybenzimidazole, 99%

MDL
MFCD00134581
EINECS
253-326-2

Chemical Properties

Formula
C8H8N2OS
Formula Weight
180.23
Melting point
255-259°
Storage & Sensitivity
Ambient temperatures.
Solubility
Soluble in dimethyl sulfoxide. Slightly soluble in methanol. Insoluble in water.

Applications

2-Mercapto-5-methoxybenzimidazole is used in the preparation of COX-2 inhibitors. It is also employed in the preparation of compounds such as 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole and 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole. Further, it acts as a hetercocyclic building block and serves as an intermediate of drug omeprazole.

Notes

Air sensitive. Store in a cool place. Incompatible with strong oxidizing agents, acids, bases and reducing agents.

Literature References

Sawant, R.; Kawade, D. Synthesis and biological evaluation of some novel 2-phenyl benzimidazole-1-acetamide derivatives as potential anthelmintic agents. Acta Pharm. 2011, 61 (3), 353-361.

Joseph, K. M.; Larraza-Sanchez, I. Synthesis of benzyl bromides with hexabromoacetone: an alternative path to drug intermediates. Tetrahedron Lett. 2011, 52 (1), 13-16.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H317

Harmful if swallowed. May cause an allergic skin reaction.

Precautionary Statements: P261-P264b-P270-P271-P272-P280g-P301+P312-P302+P352-P304+P340-P312-P330-P333+P313-P363-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Wear protective gloves. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Rinse mouth. If skin irritation or rash occurs: Get medical advice/attention. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
3605123
Harmonized Tariff Code
2933.99
TSCA
No

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