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37052-78-1 - 2-Mercapto-5-methoxybenzimidazole, 99% - 5-Methoxy-2-benzimidazolethiol - 5-Methoxy-2-mercaptobenzimidazole - B20570 - Alfa Aesar

B20570 2-Mercapto-5-methoxybenzimidazole, 99%

CAS Number
37052-78-1
Synonyms
5-Methoxy-2-benzimidazolethiol
5-Methoxy-2-mercaptobenzimidazole

Size Price ($) Quantity Availability
5g 24.30
25g 93.60
100g 337.00
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2-Mercapto-5-methoxybenzimidazole, 99%

MDL
MFCD00134581
EINECS
253-326-2

Chemical Properties

Formula
C8H8N2OS
Formula Weight
180.23
Melting point
255-259°
Sensitivity
Air Sensitive
Solubility
Soluble in dimethyl sulfoxide. Slightly soluble in methanol. Insoluble in water.

Applications

2-Mercapto-5-methoxybenzimidazole is used in the preparation of COX-2 inhibitors. It is also employed in the preparation of compounds such as 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfonyl]-1H-benzimidazole and 5-methoxy-2-[[(4-methoxy-3,5-dimethylpyridin-2-yl-1-oxide)methyl]sulfonyl]-1H-benzimidazole. Further, it acts as a hetercocyclic building block and serves as an intermediate of drug omeprazole.

Notes

Air sensitive. Store in a cool place. Incompatible with strong oxidizing agents, acids, bases and reducing agents.

Literature References

Sawant, R.; Kawade, D. Synthesis and biological evaluation of some novel 2-phenyl benzimidazole-1-acetamide derivatives as potential anthelmintic agents. Acta Pharm. 2011, 61 (3), 353-361.

Joseph, K. M.; Larraza-Sanchez, I. Synthesis of benzyl bromides with hexabromoacetone: an alternative path to drug intermediates. Tetrahedron Lett. 2011, 52 (1), 13-16.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
3605123
Harmonized Tariff Code
2933.99
TSCA
No

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