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1126-09-6 - Ethyl isonipecotate, 98% - Ethyl piperidine-4-carboxylate - H-DL-Inp-OEt - B20601 - Alfa Aesar

B20601 Ethyl isonipecotate, 98%

CAS Number
1126-09-6
Synonyms
Ethyl piperidine-4-carboxylate
H-DL-Inp-OEt

Size Price ($) Quantity Availability
25g 38.70
100g 102.00
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Ethyl isonipecotate, 98%

MDL
MFCD00006003
EINECS
214-416-7

Chemical Properties

Formula
C8H15NO2
Formula Weight
157.21
Boiling Point
203-205°
Flash Point
80°(176°F)
Density
1.021
Refractive Index
1.4600
Solubility
Fully miscible with water.

Applications

It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.

Notes

Store at room temperature. Incompatible with strong oxidizing agents.

Literature References

Samantha J. Barry.; Richard M. Carr.; Stephen J. Lane.; William J. Leavens.; Soraya Monté.; Ian Waterhouse. Derivatisation for liquid chromatography/electrospray mass spectrometry: synthesis of pyridinium compounds and their amine and carboxylic acid derivatives.rapid communications in mass spectroscopy. 2003 , 17 (6),603-620 .

Stephen A. Kolodziej.; Susan L. Hockerman.; Gary A. DeCrescenzo.; Joseph J. McDonald.; Debbie A. Mischke.; Grace E. Munie.; Theresa R. Fletcher.; Nathan Stehle.; Craig Swearingen.; Daniel P. Becker. MMP-13 selective isonipecotamide α-sulfone hydroxamates.Bioorg. Med. Chem. Lett. 2010, 20 (12),3561-3564 .

GHS Hazard and Precautionary Statements

Hazard Statements: H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Beilstein
118419
Harmonized Tariff Code
2933.39
TSCA
No

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