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It is used as a reactant for synthesis of SMN protein modulators, β-aryl and β-amino-substituted aliphatic esters by rhodium catalyzed tandem double bond migration/conjugate addition, nitroethylenediamines by nucleophilic ring opening of nitroimidazolidinone. It is also involved in the reactions of RhoA inhibitors for cardiovascular disease therapy and saccharin derived Mannich bases as antimicrobials and antioxidants. It is employed as a reactant for one-pot reductive amination and Suzuki-Miyaura cross coupling of formyl aryl and heteroaryl MIDA boronates.
Samantha J. Barry.; Richard M. Carr.; Stephen J. Lane.; William J. Leavens.; Soraya Monté.; Ian Waterhouse. Derivatisation for liquid chromatography/electrospray mass spectrometry: synthesis of pyridinium compounds and their amine and carboxylic acid derivatives.rapid communications in mass spectroscopy. 2003 , 17 (6),603-620 .
Stephen A. Kolodziej.; Susan L. Hockerman.; Gary A. DeCrescenzo.; Joseph J. McDonald.; Debbie A. Mischke.; Grace E. Munie.; Theresa R. Fletcher.; Nathan Stehle.; Craig Swearingen.; Daniel P. Becker. MMP-13 selective isonipecotamide α-sulfone hydroxamates.Bioorg. Med. Chem. Lett. 2010, 20 (12),3561-3564 .
Hazard Statements: H227-H315-H319-H335
Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210u-P261-P280a-P305+P351+P338-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.