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Ethyl trifluoropyruvate acts as a building block in synthetic chemistry for the synthesis of fluorine containing compounds. It is also used as a reagent for the preparation of potential biologically active compounds like highly enantioselective organocatalytic hydroxyalkylation of indoles.
Li, K.; Zhao, X. M.; Yang, F. L.; Hou, X. H.; Xu, Y.; Guo, Y. C.; Hao, X. Q.; Song, M. P. Catalyst-free Friedel-Crafts hydroxyalkylation of imidazo[1,2-alpha]pyridines with ethyl trifluoropyruvate. RSC Adv. 2015, 5 (110), 90478-90481.
Montesinos-Magraner, M.; Vila, C.; Blay, G.; Fernández, I.; Muioz, M. C.; Pedro, J. R. Organocatalytic Enantioselective Friedel-Crafts Alkylation of 1-Naphthol Derivatives and Activated Phenols with Ethyl Trifluoropyruvate. Adv. Synth. Catal. 2015, 357 (14-15), 3047-3051.
Hazard Statements: H226-H315-H319-H335
Flammable liquid and vapour. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P260-P201-P280a-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves and eye/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.