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B20617 4-Fluoro-2-(trifluoromethyl)benzonitrile, 98+%

CAS Number
194853-86-6
Synonyms
2-Cyano-5-fluorobenzotrifluoride
alpha,alpha,alpha,4-Tetrafluoro-o-tolunitrile

Stock No. Size Price ($) Quantity Availability
B20617-03 1g 52.90
B20617-06 5g 194.00
B20617-14 25g 807.00
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4-Fluoro-2-(trifluoromethyl)benzonitrile, 98+%

MDL
MFCD00061283
EINECS
000-000-0

Chemical Properties

Formula
C8H3F4N
Formula Weight
189.11
Melting point
43-45°
Boiling Point
194-196°
Density
1.350
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water. Solubility in methanol is almost transparent.

Applications

It is used as a pharmaceutical intermediate. It is also used for the synthesis of diphenylthioethers.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Jie Jack Li, et al. Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications.J. Med. Chem.,2008,51(21), 7010-7014.

Lorna Mitchell, et al. 4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.Bioorganic & Medicinal Chemistry Letters.2009,19(5), 1310-1313.

GHS Hazard and Precautionary Statements

Hazard Statements: H301+H311+H331-H315-H319-H335

Toxic if swallowed. Toxic in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P311-P312-P330-P332+P313-P361-P363-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Rinse mouth. If skin irritation occurs: Get medical advice/attention. Remove/Take off immediately all contaminated clothing. Wash contaminated clothing before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Hazard Class
6.1
Packing Group
III
Harmonized Tariff Code
2926.90
TSCA
No

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