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2,4-Dichlorobenzoyl chloride was used in the synthesis of biaryls by following the Suzuki coupling1. It was used for acylation in the synthesis of potent non-sarcosine-derived Gly T1 inhibitors. 2,4-Dichlorobenzoyl chloride was used in the synthesis of thioesters of 4-chlorobenzoate and 2,4-dichlorobenzoate.
Donald W. Combs.; Kimberly Reese.; Lyndon A. M. Cornelius.; Joseph W. Gunnet.; Ellen V. Cryan.; Kay S. Granger.; Jerold J. Jordan.; Keith T. Demarest. Nonsteroidal Progesterone Receptor Ligands. 2. High-Affinity Ligands with Selectivity for Bone Cell Progesterone Receptors. J. Med. Chem. 1995, 38 (25),4880-4884 .
Hazard Statements: H314-H318
Causes severe skin burns and eye damage. Causes serious eye damage.
Precautionary Statements: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a
Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.