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56-75-7 - (R,R)-Chloramphenicol, 99+% - Chloromycetin - B20841 - Alfa Aesar

B20841 (R,R)-Chloramphenicol, 99+%

CAS Number
56-75-7
Synonyms
Chloromycetin

Size Price ($) Quantity Availability
25g 46.71
100g 135.96
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(R,R)-Chloramphenicol, 99+%

MDL
MFCD00078159
EINECS
200-287-4

Chemical Properties

Formula
C11H12Cl2N2O5
Formula Weight
323.14
Melting point
149-152°
Solubility
Soluble in alcohol, propylene, glycol, acetone and ethyl acetate. Slightly soluble in water.

Applications

Inhibitor of translation on the 50S subunit at the peptidyltransferase step. (R,R)-Chloramphenicol is widely utilized as an antibiotic, which is used for the treatment of number of bacterial infections and also act as a bacteriostatic. It is often used for bacterial selection in molecular biology applications. It also finds an application in ophthalmic and veterinary purposes. It also protects the mitochondrial and chloroplast protein synthesis and ribosomal formation of (p)ppGpp, de-pressing rRNA transcription.

Notes

Keep the container tightly sealed. Incompatible with strong oxidizing agents.

Literature References

Fedeniuk, R. W.; Mizuno, M.; Neiser, C.; O’Byrne, C. Development of LC-MS/MS methodology for the detection/determination and confirmation of chloramphenicol, chloramphenicol 3-O- β-d-glucuronide, florfenicol, florfenicol amine and thiamphenicol residues in bovine, equine and porcine liver. J. Chromatogr. B 2015, 991, 68-78.

Mitchell, S. M.; Ullman, J. L.; Teel, A. L.; Watts, R. J. Hydrolysis of amphenicol and macrolide antibiotics: Chloramphenicol, florfenicol, spiramycin, and tylosin. Chemosphere 2015, 134, 504-511.

GHS Hazard and Precautionary Statements

Hazard Statements: H350-H361-H303

May cause cancer. Suspected of damaging fertility or the unborn child. May be harmful if swallowed.

Precautionary Statements: P201-P281-P202-P312-P308+P313-P405-P501a

Obtain special instructions before use. Use personal protective equipment as required. Do not handle until all safety precautions have been read and understood. Call a POISON CENTER or doctor/physician if you feel unwell. IF exposed or concerned: Get medical advice/attention. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,2077
Beilstein
2225532
Harmonized Tariff Code
2941.40
TSCA
Yes
RTECS
AB6825000

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