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It is employed as a dopamine D1 receptor antagonist and a D1DR and D2DR inhibitor. Fluphenazine Dihydrochloride has been used to deliver Fluphenazine to biological systems in studies probing the effects and metabolic fates of this commonly used dopamine antagonist. It is also employed as an antipsychotic.
G Cai, et al. Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein.Mol Pharmacol.199956(5), 989-996.
Trzeciak HI, et al. Behavioral effects of withdrawal of fluphenazine after long-term treatment. Arzneimittelforschung.1976,26(9), 1697-700.
Hazard Statements: H302
Harmful if swallowed.
Precautionary Statements: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.