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It is primarily used an intermediate in the manufacture of pharmaceutical and agrochemical products. Methyl cyclopropane carboxylate is used as a reagent in the synthesis of N-thiazole and N-pyrazole based inhibitors of MAP kinase p38α.
Matthäus Getlik, et al. Structure-based design, synthesis and biological evaluation of N-pyrazole, N?-thiazole urea inhibitors of MAP kinase p38α.Eur. J. Med. Chem.2012481-15.
Roseann Kroeker Sachs, et al. 3-Carbomethoxycyclopropen-3-yl Anion. Formation and Characterization of an Antiaromatic Ion. J. Am. Chem. Soc.,1994,116(2), 783-784.
Hazard Statements: H225-H302-H311-H319
Highly flammable liquid and vapour. Harmful if swallowed. Toxic in contact with skin. Causes serious eye irritation.
Precautionary Statements: P210-P233-P240-P243-P264b-P270-P280-P301+P312-P302+P352-P305+P351+P338-P312-P330-P337+P313-P362-P372-P374-P380-P501c
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Keep container tightly closed. Ground/bond container and receiving equipment. Take precautionary measures against static discharge. Wash face, hands and any exposed skin thoroughly after handling Do not eat, drink or smoke when using this product. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. IF ON SKIN: Wash with plenty of soap and water. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Rinse mouth. If eye irritation persists: Get medical advice/attention. Take off contaminated clothing and wash before reuse. Explosion risk in case of fire. Fight fire with normal precautions from a reasonable distance. Evacuate area. Dispose of contents/ container to an approved waste disposal plant