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It is primarily used an intermediate in the manufacture of pharmaceutical and agrochemical products. Methyl cyclopropane carboxylate is used as a reagent in the synthesis of N-thiazole and N-pyrazole based inhibitors of MAP kinase p38α.
Matthäus Getlik, et al. Structure-based design, synthesis and biological evaluation of N-pyrazole, N?-thiazole urea inhibitors of MAP kinase p38α.Eur. J. Med. Chem.2012481-15.
Roseann Kroeker Sachs, et al. 3-Carbomethoxycyclopropen-3-yl Anion. Formation and Characterization of an Antiaromatic Ion. J. Am. Chem. Soc.,1994,116(2), 783-784.
Hazard Statements: H225-H302-H331-H319
Highly flammable liquid and vapour. Harmful if swallowed. Toxic if inhaled. Causes serious eye irritation.
Precautionary Statements: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.