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2-Amino-5-nitrophenol has been used as starting material in the synthesis of series of (Z)-2-(substituted aryl)-N-(3-oxo-4-(substituted carbamothioyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl) hydrazine carboxamides, as semi permanent (nonoxidative) hair colorant and as toner in permanent (oxidative) hair dye products, in synthesis of series of 7-benzylamino-2H-1,4-benzoxazin-3(4H)-ones, anticonvulsant agents. Also used as a reactant for, diazotation and coupling reactions, preparation of biologically and pharmacologically active molecules. It is also applied in hair dyes and to make azo dyes.
Christina L Burnett, et al. Final report on the safety assessment of amino nitrophenols as used in hair dyes.Int J Toxicol.,2009,28(6), 217S-251S .
Nadeem Siddiqui, et al. Anticonvulsant and toxicity evaluation of newer 4H-benzo[1,4]oxazin-3-ones: The effect of two hydrogen bonding domains.Arch Pharm (Weinheim).,2010,343(11-12), 657-663.
Hazard Statements: H315-H319-H341-H335
Causes skin irritation. Causes serious eye irritation. Suspected of causing genetic defects. May cause respiratory irritation.
Precautionary Statements: P280h-P305+P351+P338
Wear protective gloves/clothing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.