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Ibuprofen is useful as a nonsteroidal anti-inflammatory research chemical. Ibuprofen is reported to inhibit the netrophil-dependent edema response of rabbit skin to C5a/PGE23. NSAID that inhibits cyclooxygenase-1 and -2.
Meade EA, et al. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.J Biol Chem.,1993268(9), 6610-4.
Myers RF and Siegel MI. Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction.Biochem Biophys Res Commun.1983,112(2), 586-94.
Hazard Statements: H302-H319-H335
Harmful if swallowed. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P261-P280i-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.