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15687-27-1 - 4-Isobutyl-alpha-methylphenylacetic acid, 99% - Ibuprofen - B20989 - Alfa Aesar

B20989 4-Isobutyl-alpha-methylphenylacetic acid, 99%

CAS Number
15687-27-1
Synonyms
Ibuprofen

Size Price ($) Quantity Availability
1g 21.84
5g 46.76
25g 143.17
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4-Isobutyl-alpha-methylphenylacetic acid, 99%

MDL
MFCD00010393
EINECS
239-784-6

Chemical Properties

Formula
C13H18O2
Formula Weight
206.29
Melting point
75-78°
Boiling Point
157°/4mm
Solubility
Insoluble in water. Soluble in ethanol (25 mg/ml), chloroform (1:1), ether (1:2), acetone (1:1.5), aqueous solutions of alkali hydroxides and carbonates, dichloromethane, methanol (50 mg/ml), and ethyl acetate.

Applications

Ibuprofen is useful as a nonsteroidal anti-inflammatory research chemical. Ibuprofen is reported to inhibit the netrophil-dependent edema response of rabbit skin to C5a/PGE23. NSAID that inhibits cyclooxygenase-1 and -2.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Meade EA, et al. Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.J Biol Chem.,1993268(9), 6610-4.

Myers RF and Siegel MI. Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction.Biochem Biophys Res Commun.1983,112(2), 586-94.

GHS Hazard and Precautionary Statements

Hazard Statements: H302-H319-H335

Harmful if swallowed. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P280-P305+P351+P338-P304+P340-P301+P312-P312-P337+P313-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. If eye irritation persists: Get medical advice/attention. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Other References

Merck
14,4881
Hazard Class
9
Harmonized Tariff Code
2916.39
TSCA
Yes
RTECS
MU6640000

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