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B21013 (+)-DIOP, 98%

CAS Number
37002-48-5
Synonyms
(+)-2,3-O-Isopropylidene-2,3-dihydroxy-1,4-bis(diphenylphosphino)butane

Stock No. Size Price ($) Quantity Availability
B21013-01 0.25g 47.20
B21013-03 1g 108.00
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(+)-DIOP, 98%

MDL
MFCD00009760
EINECS
253-307-9

Chemical Properties

Formula
C31H32O2P2
Formula Weight
498.55
Melting point
88-90°
Storage & Sensitivity
Keep Cold. Air Sensitive.
Solubility
Sparingly soluble in water at 25°C 2.1E-5 g/L.

Applications

It is employed as a ligand for the in situ preparation of chiral hydrogenation catalysts. It also finds it application for the in situ preparation of chiral hydrogenation catalysts, ligand for Rh(I)-catalyzed asymmetric hydrogenation of enamides, 1,4-disilylation of α,β-unsaturated ketones, Heck reaction of alkenyl iodides, and hydroformylation of olefins.

Notes

Air sensitive. Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

Yoshiaki Takaya, et al. Rhodium-Catalyzed Asymmetric 1,4-Addition of Aryl- and Alkenylboronic Acids to Enones.J. Am. Chem. Soc.,1998120(22), 5579-5580.

Kilian Muñiz, et al. Configurational Control in Stereochemically Pure Ligands and Metal Complexes for Asymmetric Catalysis.Chem. Eur. J.,2000,6(13), 2309-2316.

Ligand for the in situ preparation of chiral hydrogenation catalysts: J. Am. Chem. Soc., 94, 6429 (1972); Helv. Chim. Acta, 57, 2487 (1974); J. Org. Chem., 44, 3741 (1979).

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
1630280
Harmonized Tariff Code
2932.99
TSCA
No

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