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It is applied as a reactant in synthesis of indolylhydroxyoxindoles via enantioselective Friedel-Crafts reaction, in synthesis of benzyl trimethoxyindoles, for synthesis of benzoylpiperazinyl-indolyl ethane dione derivatives as HIV-1 inhibitors, for synthesis of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors and for preparation of tryptophanol derivatives via the Grignard reaction. It is an indole derivative as analgesic anti-inflammatory useful in treatment of pain, inflammation. It is also used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide.
F Chimenti, et al. [Monoamine oxidase inhibitors. I. Synthesis of N-cyclopropyltryptamines].Farmaco Sci.198035(9), 785-90.
Charles F. Huebner, et al. A Dimethoxy Substituted Harman and Other Compounds Derived from 5,6-Dimethoxyindole.J. Am. Chem. Soc.,195375(23), 5887-5890.