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B21126 5,6-Dimethoxyindole, 98%

CAS Number
14430-23-0
Synonyms

Stock No. Size Price ($) Quantity Availability
B21126-01 0.25g 74.60
B21126-03 1g 242.00
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5,6-Dimethoxyindole, 98%

MDL
MFCD00005675
EINECS
238-402-5

Chemical Properties

Formula
C10H11NO2
Formula Weight
177.20
Melting point
154-160°
Boiling Point
198°/8mm
Storage & Sensitivity
Ambient temperatures.
Solubility
Insoluble in water.

Applications

It is applied as a reactant in synthesis of indolylhydroxyoxindoles via enantioselective Friedel-Crafts reaction, in synthesis of benzyl trimethoxyindoles, for synthesis of benzoylpiperazinyl-indolyl ethane dione derivatives as HIV-1 inhibitors, for synthesis of 1-aroylindole 3-aroylindoles combretastatin A-4 analogs as antitumor agents and tubulin polymerization inhibitors and for preparation of tryptophanol derivatives via the Grignard reaction. It is an indole derivative as analgesic anti-inflammatory useful in treatment of pain, inflammation. It is also used in the synthesis of N-benzyl-N-cyclopropyl-5,6-dimethoxyindole-3-glyoxalamide.

Notes

Store away from oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Literature References

F Chimenti, et al. [Monoamine oxidase inhibitors. I. Synthesis of N-cyclopropyltryptamines].Farmaco Sci.198035(9), 785-90.

Charles F. Huebner, et al. A Dimethoxy Substituted Harman and Other Compounds Derived from 5,6-Dimethoxyindole.J. Am. Chem. Soc.,195375(23), 5887-5890.

GHS Hazard and Precautionary Statements

Hazard Statements: H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Precautionary Statements: P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362-P501c

Avoid breathing dust/fume/gas/mist/vapours/spray. Wash face, hands and any exposed skin thoroughly after handling Use only outdoors or in a well-ventilated area. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN: Wash with plenty of soap and water. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Call a POISON CENTER or doctor/physician if you feel unwell. If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Take off contaminated clothing and wash before reuse. Dispose of contents/ container to an approved waste disposal plant

Other References

Beilstein
5683
Harmonized Tariff Code
2933.99
TSCA
No

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