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Benzyne precursor, compare 1-Bromo-2-fluorobenzene, A10635./n
Lithiation at low temperatures with n-BuLi occurs ortho to F; subsequent reaction with electrophiles provides access to mixed dihalo derivatives such as 3-chloro-2-fluorobenzoic acid: Tetrahedron Lett., 36, 881 (1995). Improved yields are obtained by the use of the superbasic combination of n-BuLi and KO-t-Bu: Tetrahedron Lett., 37, 6551 (1996)./n
Hazard Statements: H226-H332-H315-H319-H335
Flammable liquid and vapour. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statements: P210-P261-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.